Process for preparing 3,5-difluoroaniline

C - Chemistry – Metallurgy – 07 – C

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C07C 209/10 (2006.01) C07C 17/35 (2006.01) C07C 209/74 (2006.01) C07C 211/52 (2006.01) C07C 245/20 (2006.01)

Patent

CA 2340442

The invention provides a novel process for producing a 3,5-difluoroaniline compound by reacting a 2-halo-4,6-difluoroaniline with a diazotizing agent in the presence of a reducing agent to form a diazonium salt. Build-up of potentially dangerous diazonium salt is avoided by reducing the diazonium salt with the reducing agent, to form a 1-halo-3,5- difluorobenzene, contemporaneously with the diazotization reaction. The 1-halo-3,5-difluorobenzene is then aminated.

L'invention concerne un nouveau procédé de production d'un composé de 3,5-difluoroaniline consistant à faire réagir une 2-halo-4,6-difluoroaniline avec un agent de diazotation, en présence d'un agent de réduction, afin de former un sel de diazonium. On évite de préparer des sels de diazonium potentiellement dangereux par réduction dudit sel de diazonium avec l'agent de réduction, afin de former un 1-halo-3,5-difluorobenzène simultanément à la réaction de diazotation. Puis le 1-halo-3,5-difluorobenzène est aminé.

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