Metal complexes incorporated within biodegradable...

Details Metal complexes incorporated within biodegradable... Metal complexes incorporated within biodegradable...

A - Human Necessities

61

K

A61K 31/555 (2006.01) A61K 31/28 (2006.01) A61P 31/00 (2006.01) C07F 1/00 (2006.01) C07F 1/08 (2006.01)

Patent

CA 2688412

The invention is directed to providing a compound for treating cancer, the compound comprising a metal complex having predetermined characteristics, and which may be incorporated into a polymeric nanoparticle or other delivery system for delivering the metal complex for action on tumor cells. The metal complex for treating cancer wherein the metal complex is a silver(I) salt, a silver(I) macrocyclic metal complex, a silver(I) N-heterocyclic carbene or mixtures thereof. The invention is also directed to a silver(I) macrocyclic metal complex and a silver(I) N-heterocyclic carbine, and methods of treating cancerous cells in a mammal including the steps of administering an effective amount of a silver(I) metal salt, such as by incorporating the material into a biodegradable polymeric nanoparticle.

L'invention propose un composé pour traiter le cancer, le composé comportant un complexe de métal qui présente des caractéristiques prédéterminées et qui peut être incorporé dans une nanoparticule polymère ou dans un autre système d'administration pour administrer le complexe de métal en vue d'une action sur des cellules tumorales. Le complexe de métal pour traiter le cancer est un sel d'argent (I), un complexe de métal macrocyclique d'argent (I), un carbène N-hétérocyclique d'argent (I) ou des mélanges de ceux-ci. L'invention concerne également un complexe de métal macrocyclique d'argent (I) et une carbine N-hétérocyclique d'argent (I), et des procédés de traitement de cellules cancéreuses chez un mammifère comprenant les étapes d'administration d'une quantité efficace d'un sel de métal d'argent (I), telle qu'en incorporant le matériau dans une nanoparticule polymère biodégradable.

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