Inhibitors of farnesyl-protein transferase

Details Inhibitors of farnesyl-protein transferase Inhibitors of farnesyl-protein transferase

C - Chemistry, Metallurgy

07

D

C07D 401/02 (2006.01) A61K 31/415 (2006.01) A61K 31/47 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 401/14 (2006.01)

Patent

CA 2311928

The present invention is directed to compounds which inhibit farnesyl-protein transferase (FTase) and the farnesylation of the oncogne protein Ras. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for inhibiting farnesyl-protein transferase and the farnesylation of the oncogene protein Ras.

La présente invention a trait à des composés qui inhibent la farnésyl-protéine transférase (FTase) et la farnésylation de la protéine oncogène Ras. L'invention a en outre trait à des compositions chimiothérapeutiques contenant les composés de l'invention, et à des procédés d'inhibition de la farnésyl-protéine transférase et de la farnésylation de la protéine oncogène Ras.

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