Methods and unit dose formulations for the inhalation...

Details Methods and unit dose formulations for the inhalation... Methods and unit dose formulations for the inhalation...

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/12 (2006.01) A61K 31/7036 (2006.01) A61K 51/04 (2006.01)

Patent

CA 2447600

A patient suffering from an endobronchial infection is treated by administering to the patient for inhalation a dose of less than about 4.0 ml of a nebulized aerosol formulation comprising from about 60 to about 200 mg/ml of an aminoglycoside antibiotic, such as tobramycin, in a physiologically acceptable carrier in a time period of less than about 10 minutes. Unit dose devices for storage and delivery of the aminoglycoside antibiotic formulations are also provided.

Selon la présente invention, un patient souffrant d'une infection endobronchique est traité au moyen de l'administration par inhalation d'une dose inférieure à environ 4,0 ml d'une formulation sous forme d'aérosol comprenant entre environ 60 et 200 mg/ml d'un aminoside, tel que la tobramycine, dans un excipient physiologiquement acceptable pendant une durée inférieure à environ 10 minutes. Cette invention porte sur des dispositifs de dose unitaire permettant le stockage et l'administration de formulations d'aminosides.

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