Transdermal drug delivery compositions and topical...

Details Transdermal drug delivery compositions and topical... Transdermal drug delivery compositions and topical...

A - Human Necessities

61

K

A61K 47/24 (2006.01) A61K 9/10 (2006.01) A61K 47/02 (2006.01) A61K 47/06 (2006.01) A61K 47/10 (2006.01) A61M 37/00 (2006.01) A61N 5/00 (2006.01)

Patent

CA 2645073

Transdermal delivery compositions and topical compositions for application to the skin are provided. The transdermal delivery composition includes at least two penetrants working synergistically but by disparate biochemical pathways. In one embodiment, the transdermal delivery system includes benzyl alcohol and lecithin organogel. The transdermal delivery compositions are used in a variety of topical compositions as a means of transdermally delivering and topically administering different drugs and agents, including compositions promoting collagen biosynthesis, retinoids and skin lighteners, chemical denervation agents such as BOTOX®, anti-fungal agents, anesthetics and non-steroidal anti-inflammatory drugs (NSAIDs). In addition, these topical compositions may be used in combination with non-ablative treatment modalities, such as microdermabrasion, laser-based skin remodeling and radio- frequency-based skin remodeling. LES/les

L'invention porte sur des compositions à libération transdermique et sur des compositions topiques pour application cutanée. La composition à libération transdermique précitée comprend au moins deux agents pénétrants qui travaillent en synergie, mais par des voies biochimiques différentes. Dans un mode de réalisation, le système de libération transdermique comprend de l'alcool de benzyle et un organogel de lécithine. Les compositions à libération transdermique sont utilisées dans une variété de compositions topiques comme moyens de libération transdermique et d'administration topique de divers agents et médicaments, y compris de compositions favorisant la biosynthèse du collagène, de rétinoïdes et de substances éclaircissant la peau, d'agents de dénervation chimique tels que le BOTOX®, d'agents antifongiques, d'anesthésiants et de médicaments anti-inflammatoires non stéroïdiens (AINS). Les compositions topiques de l'invention peuvent en outre être utilisées en combinaison avec des modalités de traitement non ablatives, telles que la microdermoabrasion, le remodelage cutané au laser et le remodelage cutané par radiofréquence.

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