Method of regulating angiogenesis unsing ryk protein

C - Chemistry – Metallurgy – 12 – N

Patent

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C12N 15/54 (2006.01) A61K 31/7088 (2006.01) A61K 38/45 (2006.01) A61K 48/00 (2006.01) A61P 9/00 (2006.01) C07K 14/71 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12Q 1/48 (2006.01) G01N 33/50 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2408349

Ryk protein was found to have a novel activity in regulating angiogenesis. New variant Ryk proteins were constructed that were useful in modulating the capillary forming activity of endothelial cells. Variant Ryk proteins, may be employed as therapeutics in diseases such as cancer, wound healing, diabetic retinopathies, macular degeneration, and cardiovascular diseases, and other diseases or clinical conditions where angiogenesis is relevant to the causation or treatment of the disease.

On a découvert que la protéine Ryk présentait une nouvelle activité dans la régulation de l'angiogénèse. On a construit des nouveaux variants des protéines Ryk qui sont utiles dans la modulation de l'activité de formation des capillaires des cellules endothéliales. On peut utiliser des protéines Ryk variantes en tant qu'agents thérapeutiques dans des maladies telles que le cancer, la cicatrisation des plaies, des rétinopathies diabétiques, la dégénérescence de la macula et des maladies cardio-vasculaires, ainsi que d'autres maladies ou états cliniques dans lesquels l'angiogénèse joue un rôle important dans les causes à l'origine de la maladie et le traitement de celle-ci.

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