Process for preparation of indolopyrrolocarbazole derivatives

Details Process for preparation of indolopyrrolocarbazole derivatives Process for preparation of indolopyrrolocarbazole derivatives

C - Chemistry, Metallurgy

12

P

C12P 19/38 (2006.01) C12N 1/20 (2006.01) C12P 19/28 (2006.01)

Patent

CA 2111283

The resultant compounds of the formula (I) have an excellent antitumor activity. A process for preparation of a compound represented by the formula (see formula I) wherein X1 and X2 each independently represent hydrogen atom, halogen atom, amino group, mono- or di-lower alkyl-amino group, hydroxyl group, lower alkoxy group, aralkoxy group, carboxyl group, lower alkoxycarbonyl group, lower alkanoyloxy group or lower alkyl group, and R is hydrogen atom, amino group, formylamino group, lower alkanoylamino group, mono- or di-lower alkylamino group, hydroxyl group, lower alkoxy group, aralkoxy group, aralkyl group or lower alkyl group, which comprises cultivating a microorganism having an ability to glycosylate a compound represented by the formula (see formula II) wherein X1, X2 and R have the same meanings as defined above, in a nutrient medium containing the compound of the above formula (II), and recovering the formed compound of the formula (I) from the culture medium.

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