A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/385 (2006.01) A01N 37/18 (2006.01) A61K 39/00 (2006.01) A61K 45/00 (2006.01) C07K 1/00 (2006.01) C07K 2/00 (2006.01)
Patent
CA 2383213
Methods for treatment and prevention of graft rejection, e.g., in response to tissue or organ transplantation, are disclosed. The disclosed methods comprise administration of compositions of complexes of heat shock/stress protein (hsps) including, but not limited to, hsp70, hsp90, and gp96, either alone or in combination with each other, noncovalently bound to antigenic molecules, to suppress the immune response to the grafted tissue or organ. In addition, administration of compositions containing un-complexed stress proteins (i.e., free of antigenic molecules) to suppress the immune response to the grafted tissue or organ are also disclosed. The invention encompasses administration of heat shock proteins before, after, or both before and after transplantation or grafting. In addition, the invention encompasses administration of donor tissue sample prior to administration of heat shock protein and subsequent transplantation or grafting.
L'invention porte sur un procédé de traitement et de prévention des rejets de greffes suite par exemple à une transplantation d'organe. Ledit procédé consiste à administrer une composition de complexes de protéines de choc thermique dont non exclusivement des hsp70, hsp90, et gp96, soit seules, soit combinées, et non liées par covalence à des molécules d'antigènes pour supprimer la réponse immunitaire vis-à-vis du tissu ou de l'organe greffé. L'invention porte également sur l'administration de compositions contenant des protéines de choc non complexées (c.-à-d. exemptes de molécules d'antigène) pour supprimer la réponse immunitaire vis-à-vis du tissu ou de l'organe greffé. L'invention préconise l'administration des protéines de choc thermique avant ou après ou avant et après la transplantation et l'administration d'échantillons de tissus du donneur avant celle des protéines de choc thermique et la transplantation ou la greffe.
Chandawarkar Rajiv Y.
Srivastava Pramod K.
Fordham University
Osler Hoskin & Harcourt Llp
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