Hematopoietic progenitor cell gene transduction

Details Hematopoietic progenitor cell gene transduction Hematopoietic progenitor cell gene transduction

C - Chemistry, Metallurgy

12

N

C12N 15/87 (2006.01) C12N 5/078 (2010.01) C12N 5/10 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2338344

Genetically engineered hematopoietic progenitor cells that carry within them genes of interest, particularly for the expression of physiologically or pharmacologically active proteins. The hematopoietic progenitor cells are transduced in the presence of human mesenchymal stem cells which enhance transduction efficiency.

L'invention porte sur des cellules progénitrices hématopoïétiques obtenues par génie génétique et qui comportent des gènes, notamment l'expression de protéines physiologiquement et pharmacologiquement actives. Les cellules progénitrices hématopoïétiques sont transduites en présence de cellules souches mésenchymateuses humaines qui améliorent l'efficacité de la transduction.

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