Method of inhibiting biosynthesis of eif5a

Details Method of inhibiting biosynthesis of eif5a Method of inhibiting biosynthesis of eif5a

A - Human Necessities

61

K

A61K 31/505 (2006.01) A61K 31/13 (2006.01) A61K 31/131 (2006.01) A61K 31/132 (2006.01) A61K 31/135 (2006.01) A61K 31/506 (2006.01) A61K 31/785 (2006.01)

Patent

CA 2264745

A methcsd and pharmaceutical composition for inhibiting or preventing the intracellular biosynthesis of EIf5A by the administration to a human or non-human mammal in need thereof an amount of a polyamine analogue or salt thereof sufficient to deplete the supply of intracellular spermidine required for EIfSA biosynthesis.

L'invention porte sur un procédé et une préparation pharmaceutique inhibant ou prévenant la biosynthèse intracellulaire de l'EIf5A consistant à administrer à l'homme et aux mammifères le nécessitant une dose d'un analogue de la polyamine ou d'un sel de celle-ci suffisante pour réduire l'alimentation en spermidine intracellulaire nécessaire à la biosynthèse de l'EIf5A.

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