C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) C07K 7/08 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 14/82 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/574 (2006.01)
Patent
CA 2249742
Compounds and methods for treating and diagnosing prostate cancer are provided. The inventive compounds include polypeptides containing at least a portion of a prostate protein. Vaccines and pharmaceutical compositions for immunotherapy of prostate cancer comprising such polypeptides or DNA molecules encoding such polypeptides are also provided. The inventive polypeptides may also be used to generate antibodies useful for the diagnosis and monitoring of prostate cancer. Nucleic acid sequences for preparing probes, primers, and polypeptides are also provided.
Composés et méthodes de traitement et de diagnostic pour le cancer de la prostate. Les composés décrits contiennent des polypeptides incluant au moins une partie d'une protéine de la prostate. Sont également décrits des vaccins et des compositions pharmaceutiques pour l'immunothérapie du cancer de la prostate contenant ces polypeptides ou les molécules d'ADN codant ces polypeptides. Les polypeptides décrits peuvent également être utilisés pour produire des anticorps utiles au diagnostic et à la surveillance du cancer de la prostate. L'invention concerne en outre des séquences d'acides nucléiques utilisées pour la préparation des sondes, des amorces et des polypeptides.
Dillon Davin C.
Reed Steven G.
Twardzik Daniel R.
Corixa Corporation
Gowling Lafleur Henderson Llp
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