Use of submicron oil-in-water emulsions with dna vaccines

Details Use of submicron oil-in-water emulsions with dna vaccines Use of submicron oil-in-water emulsions with dna vaccines

A - Human Necessities

61

K

A61K 9/00 (2006.01) A61K 9/10 (2006.01) A61K 31/70 (2006.01) A61K 39/00 (2006.01) A61K 39/12 (2006.01) A61K 39/21 (2006.01) A61K 39/29 (2006.01) A61K 9/107 (2006.01)

Patent

CA 2295740

The use of submicron oil-in-water emulsions with nucleic acid immunization techniques is disclosed. The method includes immunization with vaccine compositions containing nucleic acid molecules encoding one or more antigens of interest, as well as administration of a submicron oil-in-water adjuvant, such as MF59. The adjuvant can be administered either before, after or simultaneously with the nucleic acid vaccines.

Cette invention concerne l'utilisation d'émulsions huile dans eau submicroniques avec des techniques d'immunisation par acides nucléiques. Le procédé comprend l'immunisation avec des compositions vaccinales contenant des molécules d'acides nucléiques codant au moins un antigène spécifique, ainsi que l'administration d'un adjuvant huile dans eau submicronique tel que MF59. L'adjuvant peut être administré avant, après ou bien en même temps que les vaccins à base d'acides nucléiques.

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