C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 323/47 (2006.01) A61K 31/17 (2006.01) C07C 317/32 (2006.01)
Patent
CA 2178833
Certain novel phenylthiophenylcycloalkenyl hydroxyurea compounds having the ability to inhibit the 5-lipoxygenase enzyme and having formula (I) and the pharmaceutically acceptable salts thereof, wherein A and B, independently, are hydrogen, halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 halo-substituted alkyl or C1-C4 halo-substituted alkoxy; R1 and R2, independently, are hydrogen or C1-C3 alkyl; X is S, SO or SO2; and Z is methylene or ethylene. These compounds are useful in the treatment or alleviation of inflammatory diseases, allergy and cardiovascular diseases in mammals and as the active ingredient in pharmaceutical compositions for treating such conditions.
Nouveaux composés hydroxyuréiques de cycloalcényle phénylthiophényle capables d'inhiber la 5-lipoxygénase, et répondant à la formule (I), et sels pharmaceutiquement acceptables desdits dérivés. Dans ladite formule, A et B sont indépendamment hydrogène, halogène, alkyle C¿1?-C¿4?, alcoxy C¿1?-C¿4?, alkyle C¿1?-C¿4? substitué par halo ou alcoxy C¿1?-C¿4? substitué par halo, R¿1? et R¿2? sont indépendamment hydrogène ou alkyle C¿1?-C¿3?, X est S, SO ou SO¿2? et Z est méthylène ou éthylène. Ces composés sont utiles pour traiter ou soulager les maladies inflammatoires, les allergies et les maladies cardio-vasculaires chez les mammifères et en tant que principe actif dans des compositions pharmaceutiques destinées à traiter lesdits états pathologiques.
Kawai Akiyoshi
Stevens Rodney W.
Pfizer Inc.
Smart & Biggar
LandOfFree
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