Human stem cell antigens, dna coding therefor and their use

Details Human stem cell antigens, dna coding therefor and their use Human stem cell antigens, dna coding therefor and their use

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01) G01N 33/554 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2259135

The present invention provides polynucleotides encoding stem cell antigens, the partial sequences for which were initially isolated from THP-1 and bladder tumor cDNA libraries and which identify and encode novel human stem cell antigens. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding the stem cell antigens. The invention also provides for the use of purified stem cell antigens for the diagnosis and treatment of diseases associated with the expression of the stem cell antigens. Additionally, the invention provides for antibodies, antisense molecules and inhibitors of the stem cell antigens.

L'invention concerne des polynucléotides codant des antigènes de cellules souches, dont on a isolé initialement les séquences partielles d'ADNc à partir d'une banque de cellules THP-1 et d'une banque de tissus tumoraux de la vessie, d'une part, et qui identifient et codent de nouveaux antigènes des cellules souches chez l'homme, d'autre part. On décrit des vecteurs d'expression recombinés et des cellules hôtes renfermant les séquences d'acide nucléique qui codent les antigènes de cellules souches. On décrit l'utilisation d'antigènes de cellules souches à caractère purifié pour le diagnostic et le traitement des maladies liées à l'expression des antigènes de cellules souches, et aussi les anticorps, les molécules antisens et les inhibiteurs de ces antigènes.

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