C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/12 (2006.01) A61K 31/7088 (2006.01) A61K 38/17 (2006.01) A61K 39/395 (2006.01) A61K 45/00 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2442797
The present invention relates to human secreted polypeptides, and isolated nucleic acid molecules encoding said polypeptides, useful for diagnosing and treating cancer and other hyperproliferative diseases and disorders. Antibodies that bind these polypeptides are also encompassed by the present invention. Also encompassed by the invention are vectors, host cells, and recombinant and synthetic methods for producing said polynucleotides, polypeptides, and/or antibodies. The invention further encompasses screening methods for identifying agonists and antagonists of polynucleotides and polypeptides of the invention. The present invention further encompasses methods and compositions for inhibiting or enhancing the production and function of the polypeptides of the present invention.
Cette invention se rapporte à des polypeptides sécrétés humains, ainsi qu'à des molécules d'acides nucléiques isolées codant ces polypeptides, utiles dans le diagnostic et traitement du cancer et d'autres maladies et affections hyperprolifératives. Des anticorps qui fixent ces polypeptides sont également compris dans cette invention. Sont également compris dans cette invention des vecteurs, des cellules hôtes, et des procédés de recombinaison et de synthèse permettant de produire ces polynucléotides, ces polypeptides et/ou ces anticorps. Cette invention concerne en outre des procédés de criblage permettant d'identifier des agonistes et des antagonistes de ces polynucléotides et de ces polypeptides. Cette invention concerne également des procédés et des compositions permettant d'inhiber ou d'améliorer la production et la fonction de ces polypeptides.
Rosen Craig A.
Ruben Steven M.
Human Genome Sciences Inc.
Mbm Intellectual Property Law Llp
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