Process for the preparation of (pyridyl-3)-2...

Details Process for the preparation of (pyridyl-3)-2... Process for the preparation of (pyridyl-3)-2...

C - Chemistry, Metallurgy

07

D

167/231, 195/44,

C07D 409/04 (2006.01) A61K 31/44 (2006.01) C12P 17/12 (2006.01)

Patent

CA 2028985

BREVET D'INVENTION PROCEDE DE PREPARATION DE (PYRIDYL-3)-2 TETRAHYDROTHIOPYRANNECARBOTHIOAMIDE-2-OXYDES-1-(1R,2R), LES (PYRIDYL-3)-2 TETRAHYDROTHIOPYRANNECARBOTHIOAMIDE-2- OXYDES-1-(1R,2R) AINSI OBTENUS ET LES COMPOSITIONS PHARMACEUTIQUES QUI LES CONTIENNENT RHONE-POULENC SANTE ABREGE Procédé de préparation de (pyridyl-3)-2 tétrahydrothio- pyrannecarbothioamide-2-oxydes-1-(1R,2R) de formule générale : Image (R1 = alcoyle contenant 1 à 4 atomes de carbone) par action d'un iso- thiocyanate d'alcoyle sur les sulfoxydes 1R,2R et 1R,2S de formule : Image pris seuls ou en mélange, les (pyridyl-3)-2 tétrahydropyrannecar- bothioamide-2-oxydes-1-(1R,2R) ainsi obtenus et les compositions pharmaceutiques qui les contiennent. Les (pyridyl-3)-2 tétrahydrothiopyrannecarbothioamide-2- oxydes-1-(1R,2R) sont particulièrement utiles comme anti-hyper- tenseurs.

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