N,n-substituted cyclic amine compounds

Details N,n-substituted cyclic amine compounds N,n-substituted cyclic amine compounds

C - Chemistry, Metallurgy

07

D

C07D 213/30 (2006.01) A61K 31/36 (2006.01) A61K 31/495 (2006.01) A61K 31/55 (2006.01) C07D 213/57 (2006.01) C07D 213/64 (2006.01) C07D 215/20 (2006.01) C07D 217/02 (2006.01) C07D 233/54 (2006.01) C07D 233/58 (2006.01) C07D 239/34 (2006.01) C07D 239/80 (2006.01) C07D 243/08 (2006.01) C07D 295/08 (2006.01) C07D 295/12 (2006.01) C07D 317/64 (2006.01) C07D 333/16 (2006.01) C07D 333/24 (2006.01) C07D 333/38 (2006.01)

Patent

CA 2337941

N,N-substituted cyclic amine derivatives represented by general formula (VIII) or pharmacologically acceptable salts thereof: wherein A represents aryl, etc.; E represents -CO- or -CHOH-; G represents oxygen, etc.; J represents optionally substituted aryl; R1 represents lower alkyl, etc.; Alk represents linear or branched lower alkylene; n, v, w, x and y independently represent each 0 or 1; and p represents 2 or 3. These compounds or salts thereof are efficacious in treating diseases against which calcium antagonism is efficacious. These diseases include cerebrovascular disorder at the acute stage, cerebral stroke, cerebral infarction, head injury, cerebral nerve cell death, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, brain circulatory disturbance, brain function disturbance, pain, convulsion, schizophrenia, hemicrania, epilepsy, circular psychosis, nerve degeneration diseases, brain ischemia, AIDS, complex dementia, edema, anxiety and diabetic nephropathy.

L'invention concerne des dérivés d'amine cyclique N,N-substitués correspondant à la formule générale (VIII) ou leurs sels pharmaceutiquement acceptables: (VII) dans laquelle A représente aryle, etc.; E représente -CO- ou -CHOH-; G représente oxygène, etc.; J représente aryle éventuellement substitué; R¿1? représente alkyle inférieur, etc.; Alk représente alkylène inférieur droit ou ramifié; n, v, w, x et y représente chacun indépendamment 0 ou 1 et; p représente 2 ou 3. Ces composés ou leurs sels se montrent efficaces pour traiter des maladies contre lesquelles on utilise efficacement l'antagonisme du calcium. Ces maladies comprennent les maladies vasculaires cérébrales au stade aigu, l'apoplexie, l'infarctus cérébral, les traumatismes crâniens, la mort cellulaire de nerfs cérébraux, la maladie d'Alzheimer, la maladie de Parkinson, la sclérose latérale amyotrophique, la chorée de Huntington, les troubles circulatoires du cerveau, la douleur, les convulsions, la schizophrénie, l'hémicrânie, l'épilepsie, la psychose circulaire, les affections neurodégénératives, l'ischémie du cerveau, le SIDA, la démence complexe, l'oedème, l'anxiété et la néphropathie diabétique.

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