Methods and compositions for diagnosis and treatment

Details Methods and compositions for diagnosis and treatment Methods and compositions for diagnosis and treatment

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01)

Patent

CA 2740077

The invention provides methods of diagnosing multiple sclerosis (MS) patients, including methods of identifying multiple sclerosis patients who are at increased risk of developing a secondary autoimmune disease following lymphocyte depletion, caused, e.g., by treatment with an anti-CD52 antibody. Also embraced are methods of selecting treatment regimens for MS patients, and reagents useful in the above methods.

La présente invention concerne des procédés de diagnostic de patients atteints de sclérose en plaques, comprenant des procédés didentification de patients atteints de sclérose en plaques qui présentent un risque élevé de développer une maladie auto-immune secondaire après un appauvrissement en lymphocytes, causé, par exemple, par un traitement avec un anticorps anti-CD52. La présente invention concerne en outre des procédés de sélection de régimes de traitement pour des patients atteints de sclérose en plaques, et des réactifs utiles dans les procédés ci-dessus.

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