C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/10 (2006.01) A61K 31/66 (2006.01) C07F 9/117 (2006.01) C07F 9/655 (2006.01) C12P 9/00 (2006.01) C12Q 1/02 (2006.01)
Patent
CA 2329982
Membrane-permeant phosphoinositides, including phosphatidylinositol phosphate esters, are described. A membrane-permeant phosphoinositide includes groups that neutralize the charges of the phosphate moieties of the phosphoinositide. A cell can be treated with the membrane-permeant phosphoinositide, which is then absorbed into the cell. The neutralizing groups can be removed intracellularly to afford the charged phosphoinositide.
L'invention concerne des phospho-inositides de perméation membranaire, comprenant des esters de phosphatidylinositol phosphate. Un phospho-inositide de perméation membranaire renferme des groupes qui neutralisent les charges des fragments phosphate dudit phospho-inositide. Il est possible de traiter une cellule avec ledit phospho-inositide, qui est ensuite absorbé dans ladite cellule. Les groupes neutralisants peuvent être éliminés à l'intérieur de la cellule de façon à former un phospho-inositide chargé.
Jiang Tao
Tsien Roger Y.
Mbm & Co.
The Regents Of The University Of California
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