C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 7/64 (2006.01) A61K 39/21 (2006.01) C07K 14/705 (2006.01) A61K 38/00 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2362525
Cyclic peptides containing as constituting strand(s) one or two amino acid sequences selected from among amino acid sequences Glu-Ala-Asp-Asp-Arg and Ser- Gln-Lys-Glu-Gly; and AIDS vaccines containing these cyclic peptides as the active ingredient. Preferably, a cyclic dodecapeptide represented by formula (I) and an AIDS vaccine containing this peptide as the active ingredient. From the viewpoints of absorption in vivo and antibody expression, it is desirable that active groups selected from carboxyl, amino and hydroxyl groups contained in these peptides are attached to substituents. The above cyclic dodecapeptide can neutralize the second receptor in the infection of human beings with HIV-1 virus.
La présente invention concerne des peptides cycliques contenant comme chaînes de constitution une ou deux séquences d'acides aminés choisies parmi les séquences Gu-Ala-Asp-Asp-Asp-Arg et Ser-Gln-Lys-Glu-Gly. L'invention concerne aussi des vaccins contre le SIDA contenant ces peptides cycliques comme principes actifs, et de préférence un dodécapeptide cyclique représenté par la formule (I) et un vaccin contre le SIDA contenant ce peptide comme principe actif. Considérant l'absorption in vivo et l'expression d'anticorps, il est souhaitable que des groupes actifs choisis parmi des groupes carboxyles, amino et hydroxyles contenus dans ces peptides soient attachés à des substituants. Le dodécapeptide cyclique de l'invention permet de neutraliser le second récepteur intervenant dans l'infection d'humains par le HIV-1.
Fetherstonhaugh & Co.
Nissui Pharmaceutical Co. Ltd.
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