Pteridine derivatives as protein kinase inhibitors

Details Pteridine derivatives as protein kinase inhibitors Pteridine derivatives as protein kinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 475/00 (2006.01)

Patent

CA 2570494

The invention provides a novel class of compounds, pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or deregulated kinase activity, particularly diseases or disorders that involve abnormal activation of the Abl, Bcr-abl, Bmx, c-RAF, CSK, Fes, FGFR3, Flt3, GSK3.beta. , IR, JNK1.alpha. 1, JNK2.alpha. 2, Lck, MKK4, MKK6, p70S6K, PDGFR.alpha. , Rsk1, SAPK2.alpha. , SAPK2.beta. , Syk and Trk.beta. kinases.

L'invention concerne une nouvelle catégorie de composés, des compositions pharmaceutiques les contenant, ainsi que des méthodes d'utilisation de ces composés dans le traitement ou la prévention de maladies ou de troubles associés à une activité kinase anormale ou déréglée, en particulier les maladies ou troubles impliquant l'activation anormale des kinases Abl, Bcr-abl, Bmx, c-RAF, CSK, Fes, FGFR3, Flt3, GSK3ß, IR, JNK1a1, JNK2a2, Lck, MKK4, MKK6, p70S6K, PDGFRa, Rsk1, SAPK2a, SAPK2ß, Syk et TrkB.

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