Allosteric modulators of the nmda receptor

Details Allosteric modulators of the nmda receptor Allosteric modulators of the nmda receptor

A - Human Necessities

61

K

A61K 38/10 (2006.01) A61K 38/17 (2006.01) C07K 14/435 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2124566

2124566 9407914 PCTABS00032 A new class of compounds is disclosed for the manufacture of a medicament for: 1) treating neurological, neuropsychological, neuropsychiatric, neurodegenerative, neuropsychopharmacological and functional disorders associated with excessive or insufficient activation of the glutamate subtype of the NMDA receptor; 2) treating cognitive disorders associated with suboptimal activation or deactivation of the glutamate subtype of the NMDA receptor; and 3) improving and enhancing memory, learning, and associated mental processes. The compounds of the new class, derived from the toxin Conantokin-G, act as allosteric modulators of the NMDA receptor cation channel and have effects ranging from inhibitory to partial modulatory to fully stimulatory on the polyamine or a closely associated modulatory site.

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