1-(aromatic- or...

Details 1-(aromatic- or... 1-(aromatic- or...

C - Chemistry, Metallurgy

07

D

C07D 213/30 (2006.01) A61K 31/4164 (2006.01) A61K 31/4178 (2006.01) A61K 31/4196 (2006.01) A61K 31/427 (2006.01) A61K 31/4402 (2006.01) A61K 31/4427 (2006.01) A61K 31/4436 (2006.01) A61K 31/4965 (2006.01) A61K 31/497 (2006.01) C07D 213/50 (2006.01) C07D 213/61 (2006.01) C07D 213/643 (2006.01) C07D 213/65 (2006.01) C07D 213/68 (2006.01) C07D 213/74 (2006.01) C07D 233/54 (2006.01) C07D 233/64 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 241/14 (2006.01) C07D 249/08 (2006.01) C07D 249/12 (2006.01

Patent

CA 2370500

Certain 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones are described as inhibitors of HIV integrase and inhibitors of HIV replication. These compounds are useful in the prevention or treatment of infection by HIV and the treatment of AIDS, either as compounds, pharmaceutically acceptable salts, pharmaceutical composition ingredients, whether or not in combination with other antivirals, immunomodulators, antibiotics or vaccines. Methods of treating AIDS and methods of preventing or treating infection by HIV are also described.

L'invention concerne certaines 1,3-propanediones-1-(aromatiques ou hétéroaromatiques substituées)-3-(hétéroaromatiques substituées) utilisées en tant qu'inhibiteurs d'intégrase et de réplication du VIH. Ces composés sont utiles pour la prévention ou le traitement des infections à VIH et pour le traitement du sida, en tant que composés, sels acceptables sur le plan pharmaceutique ou ingrédients de compositions pharmaceutiques, en combinaison ou pas avec d'autres antiviraux, immunomodulateurs, antibiotiques ou vaccins. L'invention concerne également des méthodes de traitement du sida ou des méthodes de prévention ou de traitement des infections à VIH.

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