A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/4412 (2006.01) A61K 31/436 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2609389
The present invention relates to pharmaceutical compositions and combinations for treating cancer, comprising a diaryl urea compound e.g. 4 {4- [3- (4- chloro-3-trifluoromethylphenyl) -ureido] -3-fluorophenoxy}-pyridine-2- carboxyli.sigma. acid methylamide and an PI3K/AKT signaling pathway inhibitor. The PI3K/AKI signaling pathway inhibitor comprises PI3 inhibitors {like celecoxilo, viridins, wortmannins} , AKT kinase inhibitors {like perifosine, triciribine} and mTOR inhibitors {like the rapamycins temsirolimus and evorolimus}.
La présente invention concerne des compositions pharmaceutiques et des combinaisons pour le traitement du cancer, comprenant un composé diarylurée par exemple la méthylamide de l'acide 4-{4-[3-(4-chloro-3-trifluorométhylphényl)-uréido]-3-fluorophénoxy}-pyridine-2-carboxylique et un inhibiteur de la voie de signalisation PI3K/AKT. L'inhibiteur de la voie de signalisation PI3K/AKT comprend des inhibiteurs de PI3 {comme le célécoxilo, les viridines, les wortmannines}, des inhibiteurs d'AKT kinase {comme la périfosine, la triciribine} et des inhibiteurs de mTOR {comme les rapamycines temsirolimus et évorolimus}.
Bernard Ingo
Scheuring Urban
Bayer Healthcare Ag
Bayer Schering Pharma Aktiengesellschaft
Fetherstonhaugh & Co.
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