Semi-synthetic taxanes with antitumor and antiangiogenetic...

Details Semi-synthetic taxanes with antitumor and antiangiogenetic... Semi-synthetic taxanes with antitumor and antiangiogenetic...

C - Chemistry, Metallurgy

07

D

C07D 305/14 (2006.01) A61K 31/335 (2006.01) C07D 305/08 (2006.01)

Patent

CA 2397591

Novel derivatives obtained by oxidation, stereospecific reduction and esterification of baccatine III and the use thereof as antitumor, antiangiogenetic and anti-arthrosis agents. The compounds of the invention have cytotoxicity comparable to that of other taxanes but lower systemic toxicity and they can be administered intravenously or orally.

L'invention porte sur de nouveaux dérivés obtenus par oxydation, réduction stéréospécifique et estérification de baccatine III et sur leur utilisation comme agents antitumoraux, antiangiogénétiques et anti-arthritiques. Les composés de l'invention ont une cytotoxicité comparable à celle d'autres taxanes, mais ont une toxicité systémique inférieure, et peuvent être administrés par voie intraveineuse ou orale.

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