Method for activating of t cell protein tyrosine phosphatase...

Details Method for activating of t cell protein tyrosine phosphatase... Method for activating of t cell protein tyrosine phosphatase...

C - Chemistry, Metallurgy

07

K

C07K 14/705 (2006.01) A61K 38/17 (2006.01) A61K 48/00 (2006.01) C07K 19/00 (2006.01) C12N 15/85 (2006.01)

Patent

CA 2563930

This invention relates to methods for activation of T cell protein tyrosine phosphatase (TCPTP) and for inhibiting tyrosine kinase signalling in an individual. The invention concerns a method for preventing or treating a disease or disorder in an individual, wherein said disease or disorder is curable by inhibiting tyrosine kinase signalling, and a method for preventing cancer, or preventing or inhibiting cancer growth, invasion or metastasis in an individual, based on activating T cell protein tyrosine phosphatase (TCPTP). The invention also concerns pharmaceutical compositions useful in the methods.

Cette invention concerne des procédés d~activation de la tyrosine phosphatase de protéine de lymphocyte T (TCPTP) et d'inhibition du signal de la tyrosine kinase chez un individu. L'invention concerne un procédé pour prévenir ou traiter une maladie ou un trouble chez un individu, chez qui la dite maladie ou trouble est soignable en inhibant le signal de la tyrosine kinase, et un procédé pour prévenir le cancer, ou prévenir ou inhiber une croissance de cancer, une invasion ou des métastases chez un individu, basé sur l'activation de la tyrosine phosphatase de protéine de lymphocyte T (TCPTP). L'invention concerne aussi des préparations pharmaceutiques utiles dans les procédés.

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