N-monosubstituted adamantyl/norbornanyl 17_beta-carbamides...

Details N-monosubstituted adamantyl/norbornanyl 17_beta-carbamides... N-monosubstituted adamantyl/norbornanyl 17_beta-carbamides...

C - Chemistry, Metallurgy

07

J

C07J 41/00 (2006.01) A61K 31/56 (2006.01) C07J 31/00 (2006.01) C07J 43/00 (2006.01) C07J 51/00 (2006.01)

Patent

CA 2045867

8358/SCM95 18112 TITLE OF THE INVENTION N-MONOSUBSTITUTED ADAMANTYL/NORBORNANYL 17.beta.-CARBAMIDES OF 3-CARBOXY-ANDROST-3,5-DIENES AS TESTOSTERONE 5a-REDUCTASE INHIBITORS ABSTRACT OF THE INVENTION N-MONOSUBSTITUTED ADAMANTYL/NORBORNANYL 17.beta.-CARBAMIDES OF 3-CARBOXY-ANDROST-3,5-DIENES AS TESTOSTERONE 5a-REDUCTASE INHIBITORS OF THE FORMULA: Image I 8358/SCM95 18112 wherein R is a hydrocarbon radical selected from substituted or unsubstituted 1- or 2-adamantyl or 1-, 2 or 7-norbornanyl and pharmaceutically acceptable salts or esters thereof. Also described is a pharmaceutical formulation. The above compounds are active as testosterone 5a-reductase inhibitors and thus are useful topically for treatment of acne, seborrhea, female hirsutism, and systemically in treatment of benign prostatic hypertrophy.

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