C - Chemistry – Metallurgy – 07 – K
Patent
C - Chemistry, Metallurgy
07
K
C07K 14/795 (2006.01) A61K 38/38 (2006.01) A61K 38/41 (2006.01) C07K 1/113 (2006.01) C07K 14/765 (2006.01) A61K 38/00 (2006.01)
Patent
CA 2195630
The invention is directed to human serum albumin-porphyrin (HSA-P) complexes which are capable of reversible oxygen binding and their uses. These complexes may be used in applications requiring physiological oxygen carriers such as in blood substitute solutions, or in applications requiring plasma expanders. Methods for the production of these complexes are provided. In a specific example, HSA-P complexes are shown to exhibit reversible oxygen binding. In another example, the HSA-P complex does not exhibit appreciable vasoactivity.
La présente invention concerne des complexes de sérumalbumine humaine- porphyrine (HSA-P) capables de fixer l'oxygène de manière réversible et leurs utilisations. Ces complexes peuvent s'utiliser dans des applications nécessitant des transporteurs physiologiques de l'oxygène comme dans les solutions de succédané du sang, ou dans des applications nécessitant des succédanées du plasma. L'invention concerne des procédés de production de ces complexes. Dans un exemple particulier, est mise en évidence la capacité des complexes HSA-P de fixer l'oxygène de manière réversible. Dans un autre exemple, le complexe HSA-P ne fait pas preuve d'une vasoactivité appréciable.
Duke University
Osler Hoskin & Harcourt Llp
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