A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/48 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 25/28 (2006.01)
Patent
CA 2618508
The present invention provides novel methods of reducing memapsin 2 .beta.- secretase activity in a subject, decreasing levels of .beta.-amyloid peptide in the brain of a subject, treating Alzheimer's disease and/or reducing the size and/or number of .beta.-amyloid plaques in the brain of a subject. The methods may include the step of administering an effective amount of truncated memapsin 2 protein, anti-truncated memapsin 2 antibody, and/or nucleic acid encoding a truncated memapsin 2 protein or anti-truncated memapsin 2 antibody. The present invention also provides related pharmaceutical compositions and uses thereof.
L'invention porte sur des méthodes réduisant l'activité de la secrétase de la mémapsine 2 ß chez un patient, abaissant le niveau du peptide ß-amyloïde dans le cerveau du patient, et traitant la maladie d'Alzheimer et/ou réduisant la taille ou le nombre des plaques de ß-amyloïde dans le cerveau du patient. Lesdits procédés consistent à administrer une quantité efficace de mémapsine 2 tronquée, un anticorps anti mémapsine 2 tronquée et/ou un acide nucléique codant pour la mémapsine 2 tronquée ou un anticorps anti mémapsine 2 tronquée L'invention porte également les préparations pharmaceutiques associées et leurs utilisations.
Chang Wan Pin
Downs Deborah
Tang Jordan
Goudreau Gage Dubuc
Oklahoma Medical Research Foundation
LandOfFree
Truncated memapsin 2 for use for treating alzheimer's disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Truncated memapsin 2 for use for treating alzheimer's disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Truncated memapsin 2 for use for treating alzheimer's disease will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1974117