Method of determination of receptor binding saturation...

Details Method of determination of receptor binding saturation... Method of determination of receptor binding saturation...

G - Physics

01

N

G01N 33/53 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2731632

The invention relates to the determination of the degree of membrane receptor binding by specific monoclonal antibodies. This method is notably beneficial for monoclonal antibodies that are used in targeted therapies in order to define a target effective dose (TED). Especially the invention relates to the determination of the saturation degree of receptor binding effected by an anti-EGFR antibody of interest.

La présente invention concerne la détermination du degré de liaison aux récepteurs membranaires par des anticorps monoclonaux spécifiques. Ce procédé est notamment bénéfique pour les anticorps monoclonaux qui sont utilisés dans des thérapies ciblées en vue de définir une dose efficace cible (TED). Linvention concerne notamment la détermination du degré de saturation de la liaison à un récepteur par un anticorps anti-EGFR dintérêt.

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