Compact epstein-barr virus replicons

Details Compact epstein-barr virus replicons Compact epstein-barr virus replicons

A - Human Necessities

61

K

A61K 39/12 (2006.01) A61K 39/245 (2006.01) A61K 39/25 (2006.01) C07K 14/05 (2006.01) C12N 15/869 (2006.01)

Patent

CA 2293299

Disclosed herein are nucleic acid sequences which support episomal replication in a mammalian cell. These nucleic acid sequences, which have a length of less than 3 kb, include (a) a deleted OriP sequence and (b) a deleted EBNA1 sequence operably linked to a promoter.

L'invention concerne des séquences nucléotidiques permettant la réplication épisomique d'une cellule mammifère. Ces séquences nucléotidiques, lesquelles présentent une longueur inférieure à 3 kb, comprennent (a) une délétion de séquence OriP et (b) une délétion de séquence EBNA1 liées fonctionnellement à un promoteur.

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