Medicament for viral diseases

Details Medicament for viral diseases Medicament for viral diseases

C - Chemistry, Metallurgy

07

D

C07D 261/18 (2006.01) A61K 31/41 (2006.01) A61P 1/16 (2006.01) A61P 31/12 (2006.01) C07D 261/08 (2006.01) C07D 261/14 (2006.01)

Patent

CA 2401405

Isoxazoles are highly effective anti-viral agents. Combinations of isoxazoles, dihydropyrimidines and/or lamivudine and, optionally, interferon inhibit the proliferation of HBV viruses better than conventional agents. (I) R1, R2 = (halo)alkyl, X = a bivalent group, A = aryl or heteroaryl and R3 = H or (halo)alkyl.

Les isoxazoles sont des agents antiviraux très efficaces. La présente invention concerne des combinaisons d'isoxazoles, de dihydropyrimidines et/ou de lamivudine et, éventuellement, d'interféron, qui inhibent mieux la prolifération de virus de l'hépatite B (HBV) que les agents connus jusqu'à présent.

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