C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/68 (2006.01)
Patent
CA 2725171
The invention provides methods for predicting the response to a topoisomerase Il.alpha. inhibitor therapy in an individual having cancer, wherein the methods comprise the steps of determining TIMP-I DNA aberration/TIMP-1 protein aberration in combination with determining DNA aberration in TOP2A/HER2 amplicon on chromosome 17q21 including TOP2A and HER2 or aberrations of TOP2A and ErbB2 protein expression. Further provided are methods of treating cancer by using said topoisomerase Il.alpha. inhibitor therapy. The invention also comprises a kit for the application of the methods for predicting the response to a topoisomerase Il.alpha. inhibitor therapy in an individual having cancer.
L'invention porte sur des procédés de prédiction de la réponse à une thérapie par inhibiteur de la topoisomérase IIa chez un individu ayant un cancer. Ces procédés consistent à déterminer une aberration d'ADN de TIMP-1/aberration de la protéine TIMP-1, et à déterminer conjointement une aberration d'ADN dans un amplicon TOP2A/HER2 sur le chromosome 17q21 comprenant TOP2A et HER2 ou des aberrations de l'expression protéinique de TOP2A et ErbB2. L'invention porte en outre sur des procédés de traitement du cancer à l'aide de ladite thérapie par inhibiteur de la topoisomérase IIa. L'invention porte également sur un kit pour l'application des procédés de prédiction de la réponse à une thérapie par inhibiteur de la topoisomérase IIa chez un individu ayant un cancer.
Bruenner Nils Aage
Nielsen Kirsten Vang
Borden Ladner Gervais Llp
Dako Denmark A/s
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