Antimicrobial 5-hydrazino-quinolone derivatives

Details Antimicrobial 5-hydrazino-quinolone derivatives Antimicrobial 5-hydrazino-quinolone derivatives

C - Chemistry, Metallurgy

07

D

C07D 401/04 (2006.01) A61K 31/47 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 215/56 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 487/02 (2006.01) C07D 498/06 (2006.01) C07D 498/14 (2006.01) C07D 513/04 (2006.01) C07D 513/06 (2006.01) C07D 513/16 (2006.01)

Patent

CA 2148003

2148003 9410163 PCTABS00032 Antimicrobial 5-(N-heterosubstituted amino) quinolone compounds of general formula (I), wherein (1) R1, R2 and R3 form any of a variety of quinolone and related heterocyclic structures similar to those known in the art to have antimicrobial activity; and (2) (a) R4 and R5 are, independently, hydrogen; lower alkyl; cycloalkyl; heteroalkyl; or -C(=O)-X-R8, where X is a covalent bond, N, O, or S, and R8 is lower alkyl, lower alkenyl, arylalkyl, a carbocyclic ring, or a heterocyclic ring; or (b) R4 and R5 together comprise a heterocyclic ring that includes the nitrogen to which they are bonded; and pharmaceutically-acceptable salts and biohydrolyzable esters thereof, and solvates thereof.

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