Process for the preparation of nmda antagonists

Details Process for the preparation of nmda antagonists Process for the preparation of nmda antagonists

C - Chemistry, Metallurgy

07

C

C07C 231/02 (2006.01) C07C 237/06 (2006.01)

Patent

CA 2273286

This invention relates to an improved process for the production of known amine compounds of formula (I) which are useful as medicaments, wherein: R1 and R2 are independently phenyl or 4-fluorophenyl; R3 is hydrogen, alkyl C1-4 or methoxycarbonyl; R4 is hydrogen or methyl; which comprises reaction of a compound of formula (II) with a compound of formula (III) in which R5, R6, R7, R8, R9 and R10 are independently C1-6 alkyl followed by deprotection and optionally thereafter forming a pharmaceutically acceptable salt.

Cette invention concerne un procédé amélioré permettant de produire des composés amine connus qui sont utilisés comme médicaments et qui correspondent à la formule (I) où R?1¿ et R?2¿ représentent indépendamment phényle ou 4-fluorophényle, tandis que R?3¿ représente hydrogène, alkyle C¿1-4? ou méthoxycarbonyle, et que R?4¿ représente hydrogène ou méthyle. Ce procédé consiste à faire réagir un composé correspondant à la formule (II) avec un composé correspondant à la formule (III) où R?5¿, R?6¿, R?7¿, R?8¿, R?9¿ et R?10¿ représentent indépendamment alkyle C¿1-6?. Ce procédé consiste ensuite à effectuer une déprotection, puis à préparer éventuellement un sel de ces composés acceptable sur le plan pharmaceutique.

Affiliated with

Also associated with

Rating

Process for the preparation of nmda antagonists does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process for the preparation of nmda antagonists, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process for the preparation of nmda antagonists will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-2058077