A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/55 (2006.01) A61K 31/475 (2006.01) A61K 31/513 (2006.01) A61K 31/70 (2006.01) A61K 31/7048 (2006.01) A61K 31/7076 (2006.01) A61K 33/24 (2006.01) A61K 45/06 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2402710
A method of treatment of a host with a cellular proliferative disease, comprising contacting the host with a cephalotaxine and an antiproliferative agent, each in an amount sufficient to modulate said cellular proliferative disease, is described. In some embodiments, the cephalotaxine comprises homoharringtonine (cephalotaxine, 4-methyl-2-hydroxy-2-(4-hydroxy-4-methyl pentyl) butanediocate ester). Antiproliferative agents of the invention comprise alkylating agents, intercalating agents, metal coordination complexes, pyrimidine nucleosides, purine nucleosides, inhibitors of nucleic acid associated enzymes and proteins, and agents affecting structural proteins and cytoplasmic enzymes.
Un procédé de traitement d'un hôte atteint d'une maladie proliférative cellulaire consiste à mettre l'hôte en contact avec une céphalotaxine et un agent antiprolifératif, utilisés en quantité suffisante pour moduler la maladie proliférative cellulaire. Dans certaines formes de réalisation, la céphalotaxine comprend de l'homoharringtonine (céphalotaxine, 4-méthyl-2-hydroxy-2-(4-hydroxy-4-méthyl pentyl) ester de butanediocate). Les agents antiprolifératifs selon l'invention comprennent des agents d'alkylation, des agents intercalants, des complexes de coordination de métaux, des nucléosides de pyrimidine, des nucléosides de purine, des inhibiteurs d'enzymes et de protéines associées aux acides nucléiques et des agents affectant les protéines structurelles et les enzymes cytoplasmiques.
Brown Dennis M.
Chemgenex Therapeutics Inc.
Smart & Biggar
LandOfFree
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