Irta-4 antibodies and their uses

Details Irta-4 antibodies and their uses Irta-4 antibodies and their uses

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) C07H 21/04 (2006.01) C12N 15/00 (2006.01) C12P 21/06 (2006.01) C12Q 1/68 (2006.01) C12N 5/06 (2006.01)

Patent

CA 2580967

The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to IRTA-4 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting IRTA-4, as well as methods for treating various B cell malignancies, including non- Hodgkin's lymphoma.

La présente invention porte sur des anticorps monoclonaux isolés, en particulier des anticorps monoclonaux humains, qui se lient spécifiquement à IRTA-4 avec une grande affinité. Cette invention concerne également des molécules d'acides nucléiques codant les anticorps de cette invention, des vecteurs d'expression, des cellules hôtes et des procédés permettant d'exprimer les anticorps de cette invention. Cette invention concerne en outre des immunoconjugués, des molécules bispécifiques et des compositions pharmaceutiques comprenant les anticorps de cette invention. Cette invention concerne également des procédés de détection de IRTA-4, ainsi que des méthodes de traitement de diverses tumeurs malignes développées par les lymphocytes B, telles que le lymphome non Hodgkin.

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