Use of metronidazole combined with azelaic acid for the...

A - Human Necessities – 61 – K

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A61K 31/4164 (2006.01) A61K 31/194 (2006.01) A61K 31/20 (2006.01) A61P 17/00 (2006.01)

Patent

CA 2578121

The invention relates to a pharmaceutical composition for the treatment of rosacea and to the use of one such composition for the production of a medicament that is intended for the treatment of rosacea. The invention is characterised in that the composition comprises suitable concentrations of at least metronidazole and azelaic acid such that a synergic effect can be observed between the metronidazole and the azelaic acid. The inventive composition contains azelaic acid at a concentration of less than 10 % by weight of the total weight of the composition. In particular, the invention relates to the treatment of the inflammatory component of rosacea.

L'invention concerne une composition pharmaceutique pour le traitement de la rosacée et l'utilisation d'une telle composition pour la fabrication d'un médicament destiné au traitement de la rosacée. L'invention se caractérise en ce que la composition comporte au moins du métronidazole et de l'acide azélaïque à des concentrations telles qu'un effet synergique entre le métrodinazole et l'acide azélaïque soit observable. Ladite composition a une concentration en acide azélaique inférieure à 10 % en poids du poids total de la composition. L'invention s'applique en particulier au traitement de la composante inflammatoire dans la rosacée.

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