Method or system using biomarkers for the monitoring of a...

Details Method or system using biomarkers for the monitoring of a... Method or system using biomarkers for the monitoring of a...

G - Physics

01

N

G01N 33/50 (2006.01)

Patent

CA 2755055

The present invention relates to biomarkers to monitor the activity of the compound 3-Z-[1-(4-(N-((4-methyl-piperazin-1-yl)-methylcarbonyl)-N-methyl-amino)- anilino)-1-phenyl-methylene]-6-methoxycarbonyl-2-indolinone or a pharmaceutically acceptable salt thereof, and especially its monoethanesulphonate salt form, when used alone or optionally in combination with further pharmaceutically active ingredients and/or further treatments, such as for example radiotherapy.

La présente invention porte sur des biomarqueurs destinés à surveiller l'activité du composé 3-Z-[1-(4-(N-((4-méthyl-pipérazin-1-yl)-méthylcarbonyl)-N-méthyl-amino)-anilino)-1-phényl-méthylène]-6-méthoxycarbonyl-2-indolinone ou d'un sel de qualité pharmaceutique de celui-ci, et en particulier sa forme de sel de monoéthanesulfonate, lorsqu'il est utilisé seul ou facultativement en combinaison avec d'autres ingrédients pharmaceutiquement actifs et/ou d'autres traitements, comme par exemple la radiothérapie.

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