Method for analyzing the immunosuppressant activity of ion...

Details Method for analyzing the immunosuppressant activity of ion... Method for analyzing the immunosuppressant activity of ion...

G - Physics

01

N

G01N 33/60 (2006.01) A01K 67/027 (2006.01) C12Q 1/00 (2006.01) C12Q 1/02 (2006.01) G01N 33/50 (2006.01) G01N 33/557 (2006.01)

Patent

CA 2231880

A method for analyzing the immunosuppressant activity of K v1.3 inhibitors using the mini- and micro-pig. These pig models have been found to have K v1.3 channels very similar to man and both in function and setting of membrane potential of T-lymphocytes, and respond similarly in a mixed lymphocyte reaction (MLR) to the K v1.3 channel blockers. The mini-pig and micro-pig provide useful in vivo animal models for studying the immunosuppressant activity of K v1.3 channel blockers that would be expected to function in man.

L'invention concerne un procédé d'analyse de l'activité immunosupressive des inhibiteurs de canaux ioniques de type Kv1.3 sur la base du modèle du porc miniature et de celui dit du micro-porc. On a mis en évidence chez ces modèles de porcs du canal Kv1.3 très semblables aux canaux ioniques propres à l'homme, tant du point de vue fonctionnel que sous l'angle du potentiel de membrane des lymphocytes T, et se comportant de manière analogue dans une réaction lymphocitaire mixte (MLR) par rapport aux inhibiteurs du canal Kv1.3. Les deux modèles considérés sont utiles en tant que modèles d'animaux in vivo pour l'étude de l'activité immunosuppressive des inhibiteurs du canal Kv1.3 susceptibles d'être employés avec efficacité chez l'homme.

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