Process for concentrating blood coagulation factor xiii...

Details Process for concentrating blood coagulation factor xiii... Process for concentrating blood coagulation factor xiii...

A - Human Necessities

23

J

195/39.1

A23J 1/06 (2006.01) A61K 35/16 (2006.01) A61L 2/00 (2006.01) C12N 9/10 (2006.01) A61K 38/00 (2006.01)

Patent

CA 1112565

ABSTRACT OF THE DISCLOSURE The invention relates to a process for concent- rating blood coagulation Factor XIII (Fiblin stabilizing factor) which comprises removing a fraction precipitated at a pH of 6 to 9 in a concentration of 4 to 9 % (W/V) of an alkylenoxide polymer or copolymer having a molecular weight of 2,000 to 20,000 from a crude globulin fraction obtained from human placentae by separating an albumin fraction therefrom, and then collecting the fraction precipitated in the concentration of 20 to 30 % (W/V) of said polymer or copolymer, thereby obtaining easily said blood coagulation Factor XIII free from pyrogen in good yield.

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