A - Human Necessities – 61 – K


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A61K 9/20 (2006.01) A61K 31/216 (2006.01) A61K 31/343 (2006.01) A61K 31/57 (2006.01)


CA 2694059

The invention relates to life's necessities and in particular those relating to health, more particularly a method for dissolving and improving the intestinal absorption of active ingredients which are poorly-water-soluble or water-insoluble or which cannot be turned into salts in gastric juice, containing one or more active ingredients dispersed in a polyoxyethylene 32 fatty acid ester then hot spraying said dispersion onto a granular excipient in a fluid bed. The powder mixture thus formed is distributed in pharmaceutical compositions after optional dilution in a pharmaceutically-acceptable non-toxic inert excipient. The above is of use in the production of pharmaceutical compositions containing one or more pharmaceutically-acceptable non-toxic inert excipients.

L'invention se rapporte au domaine des nécessités de la vie et plus particulièrement à celui de la santé. Elle a plus particulièrement pour objet un procédé pour mettre en solution et améliorer la résorption intestinale de principes actifs peu solubles dans l'eau ou insolubles dans l'eau ou non salifiables dans le suc gastrique d'un ou plusieurs principe (s) actif (s) dispersés dans un ester d'acide gras de polyoxyéthylène 32 puis à pulvériser à chaud cette dispersion sur un excipient granulaire en lit fluidisé. Le mélange pulvérulent ainsi formé est distribué dans des compositions pharmaceutiques après dilution éventuelle par un excipient inerte non toxique pharmaceutiquement acceptable. Application à la réalisation de compositions pharmaceutiques renfermant un ou plusieurs excipients inertes non toxiques, pharmaceutiquement acceptables.


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