1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives

Details 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/30 (2006.01) A61K 31/44 (2006.01) A61P 3/00 (2006.01) A61P 9/00 (2006.01) C07D 215/14 (2006.01) C07D 217/16 (2006.01) C07D 231/12 (2006.01) C07D 233/64 (2006.01) C07D 237/08 (2006.01) C07D 239/26 (2006.01) C07D 241/12 (2006.01) C07D 277/24 (2006.01) C07D 277/62 (2006.01) C07D 401/06 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2700277

The present invention relates to compounds of formula (1), wherein A, n, R1a to R1e and R2 to R5 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

La présente invention concerne des composés de formule (1), dans laquelle A, n, R1a à R1e et R2 à R5 sont tels que définis dans la description et dans les revendications, et leurs sels pharmaceutiquement acceptables. Les composés sont des antagonistes du récepteur aux glucocorticoïdes utiles pour le traitement et/ou la prévention de maladies telles que le diabète, la dyslipidémie, l'obésité, l'hypertension, les maladies cardiovasculaires, le déséquilibre surrénalien ou la dépression.

Affiliated with

Also associated with

Rating

1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,1,1-trifluoro-2-hydroxy-3-phenylpropane derivatives will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1391509