C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
167/246, 260/600
C07C 43/23 (2006.01) C07C 69/736 (2006.01) C07C 103/76 (1985.01)
Patent
CA 1250857
Abstract The invention relates to new 1,1-diphenylpropan-l-ol derivatives of the formula (I) Image ( I) wherein R1 and R2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms, R3 is halogen, trihalomethyl, alkyl having from one to 5 carbon atoms or alkoxy having from one to 5 carbon atoms, R4 is phenyl optionally substituted by one or more identical or different substituents selected from the group of halogen, trihalo- methyl, alkyl, alkoxy, cyano, nitro, amino, alkylamino, dialkylamino, hydroxyl or/carboxy; dialkylaminocarbonyl or alkoxycarbonyl containing from one to 4 carbon atoms in the alkyl and alkoxy moieties, respectively, n is 1, 2, 3, 4 or 5. -2- According to another aspect of the invention there are provided processes for the preparation of the compounds of formula (I). The new compounds induce the polysubstrate mono- oxigenase enzyme system of liver and are devoid from other pharmacodinamic effects. Pharmaceutical compositions containing compounds of the formula (I) as active ingredient are also within the scope of the invention.
444254
Gorog Sandor
Hajdu Istvan
Palosi Eva
Szeberenyi Szabolcs
Szporny Laszlo
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt
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