1-¬(1-substituted-4-piperidinyl)methyl|-4-piperidine...

Details 1-¬(1-substituted-4-piperidinyl)methyl|-4-piperidine... 1-¬(1-substituted-4-piperidinyl)methyl|-4-piperidine...

C - Chemistry, Metallurgy

07

D

C07D 211/58 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) A61K 31/54 (2006.01) C07D 211/96 (2006.01) C07D 405/12 (2006.01) C07D 405/14 (2006.01)

Patent

CA 2330475

Compounds represented by general formula (I) or physiologically acceptable acid addition salts thereof and medicinal compositions containing these compounds as the active ingredient, wherein Ar represents (Ar-1) or (Ar-2); and A represents -Z-N(Q1)(Q2), -CO-R7 or -(CH2)p-CH(R8)-COR9. Because of exhibiting strong affinity for 5-HT4 receptor, these compounds are useful as drugs for accelerating the peristalsis or drugs for improving digestive tract functions.

L'invention concerne des composés représentés par la formule générale (I) ci-dessous ou des sels d'addition d'acide physiologiquement acceptables de ces composés, ainsi que des compositions médicinales contenant ces composés en tant qu'ingrédient actif. Ar représente (Ar-1) ou (Ar-2) et A représente -Z-N(Q?1¿)(Q?2¿), -CO-R?7¿ ou -(CH¿2?)¿p?-CH(R?8¿)-COR?9¿. Etant donné qu'ils montrent une forte affinité pour le récepteur 5-HT¿4?, ces composés sont utiles comme médicaments accélérant les mouvements péristaltiques ou améliorant les fonctions des voies digestives.

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