C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/231, 260/272
C07D 209/16 (2006.01) C07D 401/06 (2006.01) C07D 471/04 (2006.01) C07D 471/14 (2006.01)
Patent
CA 1301171
1,12b-disubstituted octahydroindolo[2,3-a]quino- lizine derivatives, process for their preparation and pharmaceutical compositions containing them A b s t r a c t The invention relates to new racemic and optically active 1,12b-disubstituted octahydro- indolo[2,3-a]quinolizine derivatives of the for- mula (I) Image (I) wherein R1 and R2 are the same or different and represent hydrogen, halogen, nitro, alkyl having from 1 to 6 carbon atoms, alkoxy having from 1 to 6 carbon atoms or hydroxyl, R3 and R5 are the same or different and represent hydrogen, alkyl having from 1 to 6 carbon atoms or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety, - 2 - R4 is alkyl having from 1 to 6 carbon atoms, aryl or aralkyl having from 1 to 6 carbon atoms in the alkyl moiety, and R6 is an electron attracting substituent, and cis and trans isomers and acid addition salts thereof. The compounds are pharmaceutically active, in particular show an outstanding cardiovascular, e.g. selective peripheral vasodilating activity. Some of these compounds are valuable intermediates in the preparation of other, pharmaceutically active compounds,
507053
Balogh Zsuzsanna Nee Kardos
Csomor Katalin
Forgacs Lilla
Incze Maria
Karpati Egon
Balogh Zsuzsanna Nee Kardos
Csomor Katalin
Fetherstonhaugh & Co.
Forgacs Lilla
Incze Maria
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