1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles,...

Details 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles,... 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-10-oles,...

C - Chemistry, Metallurgy

07

D

C07D 221/26 (2006.01) A61K 31/435 (2006.01) A61K 31/439 (2006.01) A61P 9/10 (2006.01) A61P 23/00 (2006.01) A61P 25/00 (2006.01)

Patent

CA 2302347

The invention relates to novel substituted 1,2,3,4,5,6-hexahydro-2,6-methano-3-benzazocin-l0-oles of general formula (I) Image and to a method for the production thereof and to the use thereof as a medicament. The medicament is a sodium channel blocker, may be used as an anaesthetic or a local anaesthetic or may be used in the therapeutic treatment of a cerebral ischaemia, a neurodegenerative disorder, epilepsy, hypoglycaemia, hypoxia, anoxia, brain trauma, cerebral oedema, cerebral stroke, perinatal asphyxia, amyotropic lateral sclerosis, Huntington's disease, Alzheimer's disease, Parkinson's disease, a bipolar disorder, cyclophrenia, hypotonia, cardiac infarct, a cardiac rhythm disorder, angina pectoris or pain.

L'invention concerne de nouveaux 1,2,3,4,5,6-hexahydro-2,6-méthano-3-benzazocine-10-oles de la formule générale (I), des procédés permettant des les préparer et leur utilisation comme médicaments.

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