1,2,4-benzothiadiazine-oxide derivatives, process for their...

Details 1,2,4-benzothiadiazine-oxide derivatives, process for their... 1,2,4-benzothiadiazine-oxide derivatives, process for their...

C - Chemistry, Metallurgy

07

D

167/213, 260/243

C07D 513/04 (2006.01)

Patent

CA 1254199

ABSTRACT 1,2,4-Benzothiadiazine oxide derivatives of the general formula I Image (I) in which R1 represents a unsubstituted or substituted aryl radical, R2 and R5, which may be the same or different, and represent hydrogen, halogen or a nitro group and R3 represents a hydrogen atom or a hydroxy radical, an alkyl, alkoxy alkyl or alkoxy carbonyl radical with up to 4 carbon atoms, unsubstituted or substituted by halogen, hydroxy, amino, alkyl amino or dialkyl amino radicals, or a phenyl radical, unsubstituted or substituted by halogen, are described; a further subject is an analogy method for the preparation of these compounds. The compounds of general formula I prepared in accordance with the method possess valuable pharmacological properties, in particular they are distinguished by remarkable anxiolytic effects on the central nervous system.

490118

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