1,2,4-triazole compounds

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 401/04 (2006.01) A61K 31/4439 (2006.01) A61K 31/496 (2006.01) A61P 19/06 (2006.01) A61P 43/00 (2006.01) C07D 311/16 (2006.01) C07D 401/14 (2006.01) C07D 405/14 (2006.01) C07D 413/10 (2006.01)

Patent

CA 2462132

A novel 1,2,4-triazole compound represented by the following general formula (1): (1) wherein R2 represents unsubstituted pyridyl or pyridyl substituted by cyano, etc.; R1 represents unsubstituted pyridyl, pyridyl substituted by halogeno, etc., or phenyl substituted by cyano, etc.; and R3 represents hydrogen or pivaloyloxy-substituted lower alkyl which each is bonded to one nitrogen atom as a member of the 1,2,4-triazole ring in the general formula (1). It is useful as a therapeutic agent for hyperuricemia and gout caused by hyperuricemia.

L'invention concerne un nouveau composé 1,2,4-triazole représenté par la formule générale (1), dans laquelle R¿2? est un groupe pyridyle non substitué ou un groupe pyridyle substitué par cyano, etc., R¿1? un groupe pyridyle non substitué ou un groupe pyridyle substitué par halogéno, etc., ou un groupe phényle substitué par cyano, etc. et R¿3? est un atome d'hydrogène ou un groupe alkyle inférieur substitué par pivaloyloxy, chacun étant lié à un atome d'azote sous forme de chaînon du cycle 1,2,4-triazole. Ce nouveau composé est utile en tant qu'agent thérapeutique pour traiter l'hyperuricémie et la goutte provoquée par l'hyperuricémie.

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