C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/435 (2006.01) A61P 35/00 (2006.01) C07D 221/00 (2006.01) C07D 249/00 (2006.01)
Patent
CA 2586796
The invention provides novel, substituted 7-arylamino[1,2,4]triazolo[4,3- a]pyridine compounds Formula (I): pharmaceutically acceptable salts, solvates and prodrug compounds thereof, wherein W, R1, R2, R9, R10 R11, R12, R13, R14 and L are as defined in the specification. Such compounds are MEK inhibitors and useful in the treatment of hyperproliferative diseases, such as cancer, restenosis and inflammation. Also disclosed is the use of such compounds in the treatment of hyperproliferative diseases in mammals, especially humans, and pharmaceutical compositions containing such compounds.
La présente invention a pour objet de nouveaux dérivés substitués de 7-arylamino[1,2,4]triazolo[4,3-a]pyridine de Formule (I) : ainsi que des sels de qualité pharmaceutique, des solvates ou des prodrogues desdits dérivés, où W, R1, R2, R9, R10, R11, R12, R13, R14 et L sont tels que définis dans la description de l'invention. De tels composés sont des inhibiteurs de MEK et peuvent être employés dans le traitement de maladies hyperproliférantes, telles que le cancer, la resténose et l~inflammation. La présente invention a également pour objet l~emploi de tels composés dans le traitement de maladies hyperproliférantes chez les mammifères, en particulier les humains, ainsi que des préparations pharmaceutiques contenant de tels composés.
Abel Ulrich
Deppe Holger
Feurer Achim
Giulio Matassa Victor
Graedler Ulrich
Kirby Eades Gale Baker
Laboratoires Serono S.a.
Merck Serono Sa
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